How a prostate health supplement fits into men’s longevity

Men rarely book an appointment to talk about their urinary symptoms. Male patients typically book because their back hurts, their energy is down or they are not sleeping.

Yet urinary symptoms—especially waking at night to urinate—often sit in the background and quietly erode quality of life.

For some male patients, a prostate health supplement could be a key part of a practical care plan to holistically support sleep, movement, stress reduction and nutrition.

One option many DCs carry in their practices is Advanced Prostate Plus from Dee Cee Laboratories.

Why urinary symptoms matter for prostate health and healthy aging

Lower urinary tract symptoms begin to rise with age and are linked to worse patient outcomes in older adults. In prospective and pooled analyses, nocturia is associated with poorer sleep quality¹ and a small but meaningful increase in falls² and mortality³ over time. For DCs, that makes urinary and prostate health more than a comfort issue. It is part of maintaining independence, mobility and sound sleep as patients age.

Where a supplement can fit

Start with first‑line steps, including reviewing your patient’s hydration timing and evening caffeine and alcohol consumption. Gauge their level of regular physical activity and set a healthy weight goal if needed. Ask about their sleep hygiene: Do they sleep with TVs or smartphones on or use them right before bed? What temperature do they keep the thermostat? Are there pets in the bed with them? Give suggestions for optimizing their sleep environment as much as possible. Finally, review all medications and supplements they take, note any known allergies and offer referral to a urology provider for any potential issues that will be out of your scope.

Nutritional support for urinary problems at night: What the evidence says

When patients want nutritional support for nighttime urinary issues, some DCs consider blends that include beta‑sitosterol, pygeum, rye grass pollen extract, nettle and sometimes saw palmetto. Evidence varies by ingredient and product, and trials are typically short. Still, several ingredients have shown promise in this area.

Beta‑sitosterol: Systematic reviews of randomized trials show short‑term improvement in urinary symptom scores and peak flow vs. placebo, but long‑term outcomes are less clear.⁴

Pygeum (African plum): A quantitative meta‑analysis showed patients who took it had moderate improvements in urinary symptoms and flow vs. those who took a placebo.⁵

Rye grass pollen extract: A systematic review reported limited but positive evidence for nighttime urination frequency reduction, as well as improvement in the short term (self-rated by test subjects).⁶

Stinging nettle root: Randomized trials, including a 12‑month study and a double‑blind randomized controlled trial, suggest taking this supplement improves lower urinary tract symptoms for some men.^7,8

Saw palmetto: High‑quality reviews conclude saw palmetto alone provides little to no benefit for lower urinary tract symptoms; it is still included in many blends formulated for this purpose, but DCs should set expectations accordingly.⁹

Most research studies evaluate single ingredients, not specific branded combinations, so the effects are typically modest, measured over weeks to months, and individual response varies. When trying out any new supplement with a patient, position it as a trial with follow‑up, not as a definitive solution.

How to integrate a prostate health supplement into your practice

Here’s an approach you can take with male patients, who may be reluctant to talk about or seek out treatment for issues related to nighttime urination or prostate health.

1. Open the door. During your intake, ask matter‑of‑fact questions about sleep and nighttime bathroom trips. This normalizes the topic and may make it easier for the patient to talk about.
2. Screen first. Rule out red flags like blood in the urine, painful urination, fever or unintended weight loss. Coordinate with primary care for PSA testing, medication review or urology referral whenever appropriate.
3. Set patient goals, making them specific and achievable. Agree on clear, trackable targets and a follow-up date for each. For example, “reduce awakenings from three to one most nights.”
4. 4. Offer a trial window. If the patient is interested, consider a six- to 12-week trial of a blend such as Advanced Prostate Plus while continuing lifestyle change steps. After the trial period, reassess symptom scores and sleep quality.
5. Document outcomes and celebrate successes. Use a simple symptom checklist and the patient’s sleep notes. If the supplement is not having a benefit, make adjustments or discontinue it if need be. If the supplement is helping, continue with periodic check‑ins.
6. Mind interactions. Encourage patients to bring all prescription and supplement bottles with them to appointments with you. Check for interactions, especially with anticoagulants, hormone therapy and duplicate ingredients across products.

About Advanced Prostate Plus for prostate health

Advanced Prostate Plus combines beta‑sitosterol, saw palmetto, pygeum, rye grass pollen extract and nettle in a vegetarian capsule and is manufactured under good manufacturing practices. It is designed to nutritionally support healthy prostate function.

As with any supplement, remind patients the product is not intended to diagnose, treat, cure or prevent disease, and that individual results will vary.

Final thoughts

Many patients may not realize the treatment options, including nutritional support, that exist for issues with nighttime urination. Offering male patients help in this area can dramatically improve their well-being and quality of life.

References

1. Ancoli‑Israel S, et al. The effect of nocturia on sleep. Sleep Med Rev. 2011;15(2):91-97. https://pmc.ncbi.nlm.nih.gov/articles/PMC3137590/. Accessed August 20, 2025.
2. Vaughan CP, et al. The association of nocturia with incident falls in an elderly community-dwelling cohort. Int J Clin Pract. 2010;64(5):577-583. https://pmc.ncbi.nlm.nih.gov/articles/PMC3222329/. Accessed August 20, 2025.
3. Pesonen JS, et al. The impact of nocturia on mortality: A systematic review and meta‑analysis. J Urol. 2020;203(3):486‑495. https://pubmed.ncbi.nlm.nih.gov/31364920/. Accessed August 20, 2025.
4. Wilt TJ, et al. Beta‑sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2000;1999(2):CD001043. https://pubmed.ncbi.nlm.nih.gov/10796740/. Accessed August 20, 2025.
5. Ishani A, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: A systematic review and quantitative meta‑analysis. Am J Med. 2000;109(8):654‑664. https://pubmed.ncbi.nlm.nih.gov/11099686/. Accessed August 20, 2025.
6. MacDonald R, et al. A systematic review of Cernilton (rye grass pollen extract) for benign prostatic hyperplasia. BJU Int. 2000;85(6):836‑841. https://pubmed.ncbi.nlm.nih.gov/10792162/. Accessed August 20, 2025.
7. Schneider T, et al. Stinging nettle root extract in long‑term treatment of benign prostatic syndrome: Results of a randomized, double‑blind, placebo‑controlled multicenter study. Urologe A. 2004;43(3):302‑306. https://pubmed.ncbi.nlm.nih.gov/15045190/. Accessed August 20, 2025.
8. Ghorbanibirgani A, et al. The efficacy of stinging nettle (Urtica dioica) in patients with benign prostatic hyperplasia: A randomized double‑blind study in 100 patients. Iran Red Crescent Med J. 2013;15(1):9‑10. https://pmc.ncbi.nlm.nih.gov/articles/PMC3589769/. Accessed August 20, 2025.
9. Franco JVA, et al. Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement. Cochrane Database of Systematic Reviews 2023, Issue 6. https://www.cochrane.org/evidence/CD001423_serenoa-repens-benign-prostatic-hyperplasia. Accessed August 20, 2025.