Revolutionizing personalized care through nootropics and adaptogens

Nootropics and adaptogens are revolutionizing personalized healthcare by providing more options for improving sleep, stress, inflammation and focus.

Compounds like reishi mushroom and Bacopa monnieri, a plant native to India, have shown great potential to enhance cognitive function and overall well-being. By exploring the synergistic effects of these ingredients, we uncover how they can significantly improve patient outcomes. This article explores the science behind nootropics and adaptogens, supported by case studies and expert insights, to provide a guide for DCs interested in optimizing patient chiropractic care through these innovative solutions.

Understand the origins and definitions of nootropics and adaptogens

Nootropics and adaptogens have a rich history rooted in traditional medicine and scientific exploration. Nootropics, also known as “smart drugs,” emerged in the 1960s with the development of the drug piracetam by Romanian psychologist and chemist Corneliu E. Giurgea, PhD, who coined the term to describe substances that enhance cognitive function. These compounds are characterized by their ability to improve memory, creativity and motivation without significant side effects.¹

Adaptogens, on the other hand, have been used for centuries in Ayurveda and traditional Chinese medicine. They are defined by their ability to help the body resist stressors and maintain homeostasis. Adaptogens like ashwagandha and reishi work by modulating the stress response and enhancing resilience.^2,3 Together, nootropics and adaptogens present a synergistic opportunity for DCs to provide personalized chiropractic care.

Scientific backing and benefits

The scientific community has increasingly discovered the potential benefits of nootropics and adaptogens through rigorous research and clinical trials. Nootropics, such as Bacopa monnieri, have been shown to enhance memory and cognitive performance, particularly in aging populations. Studies indicate Bacopa monnieri may significantly improve cognitive functioning, including attention, processing speed and working memory, after 12 weeks of supplementation.⁴

Adaptogens such as ashwagandha have demonstrated significant stress-reducing properties.³ Research reveals ashwagandha can lower cortisol levels, thereby reducing stress and anxiety. Another potent adaptogen, reishi, has been found to support immune function and promote relaxation, contributing to better sleep quality.²

These findings underscore the potential of nootropics and adaptogens to improve critical health measures, making them valuable components in personalized healthcare strategies. By leveraging these natural compounds, DCs can offer patients a scientifically-backed approach to enhancing cognitive function, managing stress and improving overall well-being.

Key takeaways

• Approximately 36% of U.S. adults use some form of complementary medicine, highlighting the growing integration of natural supplements, such as nootropics and adaptogens, into modern healthcare practices​.
• Studies show the nootropic Bacopa monnieri can significantly improve memory retention and cognitive processing after several weeks of use.
• Ashwagandha, an adaptogen, reduces cortisol levels by up to 30%, significantly lowering stress and anxiety, according to clinical research​.

Synergies of combining nootropics and adaptogens in a single formula

Combining nootropics and adaptogens in a single formula can yield synergistic benefits. Pairing Rhodiola rosea, an adaptogen known for reducing stress,⁵ with Bacopa monnieri, a nootropic that boosts cognitive function, can create a balanced approach to managing stress and enhancing mental clarity. Similarly, combining reishi with l-theanine can improve sleep quality while simultaneously promoting relaxation and cognitive alertness.⁶

These synergies may occur because adaptogens help the body maintain homeostasis, providing a stable foundation for nootropics to exert their cognitive-enhancing effects, although research into the mechanisms is ongoing. By integrating these compounds, DCs can create holistic personalized treatment plans that maximize the benefits of each ingredient, leading to improved outcomes in sleep, stress management, inflammation and focus.

Key ingredients for cognitive health

Several key ingredients stand out for their efficacy in supporting cognitive health. Bacopa monnieri is well-documented for its ability to enhance memory and cognitive performance. This herb improves synaptic communication, which is vital for memory retention and learning.⁷ Lion’s mane mushroom stimulates nerve growth factor (NGF), promoting neuronal growth and safeguarding brain health. In fact, lion’s mane extract has been shown to increase neurite outgrowth by 60.6%, demonstrating its potent neurotrophic effects.⁸ Rhodiola rosea is celebrated for its adaptogenic properties, improving mental endurance and reducing fatigue. L-theanine, found in green tea, supports relaxation without drowsiness, making it ideal for enhancing focus and reducing stress. Finally, alpha GPC, a cholinergic compound, boosts acetylcholine levels, essential for cognitive functions such as learning and memory.⁹ These ingredients, used synergistically, can provide a multi-faceted approach to cognitive health, offering significant benefits to memory, focus and overall mental well-being.

Key takeaways

• Bacopa monnieri improves memory retention by enhancing synaptic communication.
• Lion’s mane mushroom increases neurite outgrowth by 60.6%, promoting brain health and neuronal growth.​
• Rhodiola rosea supports mental endurance and reduces fatigue.
• L-theanine, found in green tea, promotes relaxation and enhances focus without drowsiness.
• Alpha GPC boosts acetylcholine levels, essential for learning and memory retention.​

Transform sleep with natural compounds

Restful sleep may be significantly enhanced through the synergistic use of adaptogens and nootropics. Ashwagandha and valerian root work in tandem to promote relaxation and reduce anxiety, paving the way for improved sleep quality. Ashwagandha lowers cortisol levels, which can help calm the mind, while valerian root has been traditionally used to alleviate sleep disorders and enhance the depth of sleep.¹⁰ When combined with L-theanine for its calming effects, these compounds create a powerful blend that may support sleep onset and maintenance. Reishi contributes further by enhancing relaxation and boosting immune function during sleep. One type of reishi, specifically Ganoderma lucidum, has been shown to “significantly increase total sleep time and non-REM sleep in rats after just three days of administration.”²

By utilizing these natural compounds together, DCs can offer a holistic approach to sleep enhancement, providing patients an effective strategy to combat insomnia, potentially achieving deeper, more restorative sleep cycles.

Reduce stress through adaptogens’ ingredients

Effective stress management can be achieved using a combination of key adaptogens and nootropics. Ashwagandha reduces cortisol levels, while L-tyrosine supports stress resilience by improving cognitive performance under pressure, making it a valuable addition for those experiencing mental fatigue. In fact, clinical studies have shown that L-tyrosine supplementation can significantly reduce the cognitive decline associated with stress and fatigue, allowing individuals to maintain their focus and concentration during high-pressure situations.¹¹

Magnesium plays a crucial role in nervous system regulation and can help relax muscles and reduce stress-induced tension.¹² Valerian root offers sedative properties that can ease anxiety, contributing to a calmer mental state. Reishi further supports stress management by modulating immune response and enhancing overall resilience to stressors.

By incorporating these ingredients into stress management protocols, DCs can provide patients a natural, effective means to handle stress, fostering both mental and physical well-being.

Combat inflammation with natural synergies

Combating inflammation naturally involves leveraging the synergistic effects of specific adaptogens and nootropics. For instance, combining chaga mushroom and resveratrol can offer potent anti-inflammatory benefits.¹³ Chaga is rich in antioxidants, which help reduce oxidative stress and inflammation. Studies have shown extracts from Inonotus obliquus (chaga mushroom) significantly reduce inflammatory markers such as nitric oxide and tumor necrosis factor-alpha (TNF-α), indicating chaga’s strong potential to mitigate inflammation-related conditions.¹⁰ Resveratrol, found in grape skins, further enhances this effect by modulating inflammatory pathways and supporting cardiovascular health. Additionally, curcumin, the active compound in turmeric, has been extensively studied for its anti-inflammatory properties. It is fat-soluble and needs to be taken with a small amount of fat to improve absorption, while some studies indicate including pepper may also be beneficial.^14,15 Phosphatidylserine and alpha GPC also play crucial roles in maintaining cellular health and reducing inflammation at the neuronal level.⁹

These synergies offer a holistic approach to inflammation management, providing DCs effective natural solutions to reduce patients’ risk of chronic inflammatory conditions.

How to incorporate nootropics and adaptogens into patient care

Incorporating nootropics and adaptogens into patient care requires a strategic approach tailored to individual health needs. DCs can start by assessing a patient’s health goals, such as stress reduction, cognitive enhancement or inflammation management. Based on these objectives, select compounds that target these areas effectively.

For example, for patients seeking stress relief, consider ashwagandha and magnesium. For inflammation support, curcumin and chaga could be beneficial. For cognitive enhancement, leverage lion’s mane mushroom and Bacopa monnieri.

Educate patients on the potential benefits and any possible interactions with existing medications. Start with smaller amounts, monitoring the patient’s response, and adjust as necessary. Encourage patients to maintain a holistic lifestyle, incorporating supplements with a balanced diet and regular exercise.

Final thoughts

By incorporating nootropics and adaptogens into treatment plans, DCs can offer their patients personalized, science-backed options to enhance cognitive function, reduce stress and manage inflammation. A tailored approach strengthens the DC’s role as a leader in wellness care and may improve patient outcomes.

LUKE K. BARR, MD, is the chief medical officer of SensIQ nootropics and adaptogens. He is a neurologist and director of a comprehensive stroke center in the Midwest. He completed his residency at University of North Carolina at Chapel Hill. He specializes in caring for hospitalized patients with acute and critical neurological conditions and has special interests in traumatic brain injury, decision analysis, neuroplasticity and neurorehabilitation. Barr believes in a holistic, patient-tailored, systems-based and data-driven approach to care delivery across the entire health spectrum. He can be reached at luke@sensiqnootropics.com.

References

All accessed October 20, 2024.

1. Giurgea C. Pharmacology of integrative activity of the brain. Attempt at nootropic concept in psychopharmacology. Actual Pharmacol (Paris). 1972:25:115-56. PubMed. https://pubmed.ncbi.nlm.nih.gov/4541214/.
2. Wang Y, et al. Extract of Ganoderma lucidum prolongs sleep time in rats. Phytother Res. 2012;26(11):1605-1608. doi:10.1002/ptr.4541.
3. Chandrasekhar K, et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. PubMed. https://pubmed.ncbi.nlm.nih.gov/23439798/.
4. Pase MP, et al. The cognitive-enhancing effects of bacopa monnieri: A systematic review of randomized controlled human clinical trials. J Altern Complement Med. 2012;18(7):647-652. PubMed. https://pubmed.ncbi.nlm.nih.gov/22747190/.
5. Edwards D, et al. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms: Results of an open-label study. Phytother Res 2012;26(8):1220-1225. Wiley. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3712?msockid=3056a1a13eb96b86272fb4bd3f1e6a9c.