Doctors of chiropractic have a powerful nutritional tool to suggest to patients, Greens First Pro, which has been upgraded with a powerful new ingredient: Quatrefolic, a fourth-generation folate that bypasses common genetic and metabolic absorption limitations.
For patients with cardiovascular, cognitive, hormonal or fertility concerns—especially those with certain genetic polymorphisms—this upgrade adds clinical value to a trusted product.
Now with a highly bioavailable form of folate, Greens First Pro offers even more precise support for common conditions you encounter in practice.
Why folate matters more than folic acid
Most folate supplements contain folic acid, a synthetic form that must undergo several metabolic conversions before it becomes biologically active as 5-methyltetrahydrofolate (5-MTHF). This conversion depends heavily on the enzyme methylenetetrahydrofolate reductase (MTHFR), which is impaired in up to 40% of the general population due to common genetic polymorphisms, such as C677T and A1298C.1
Quatrefolic delivers 5-MTHF directly in a stable, bioavailable glucosamine salt form, bypassing the MTHFR bottleneck entirely. That makes it an especially smart folate choice for patients who may not metabolize folic acid efficiently—a common but underdiagnosed issue.
Which patients benefit most from folate supplementation?
While folate is vital for everyone, research shows several clinical populations specifically benefit from the active form.
Women who are pregnant or planning pregnancy derive several benefits from folate, including reducing the risk of neural tube defects2 supporting placental health and improving pregnancy outcomes,3 especially in women with undiagnosed MTHFR polymorphisms. It’s helpful for both male and female reproductive health; studies have shown it improves sperm quality and boosts pregnancy rates in couples with unexplained infertility issues.4
Several studies show that by directly supporting homocysteine metabolism, folate supplementation significantly reduces serum homocysteine,5 high levels of which are a known risk factor for cardiovascular disease. Folate also plays a key role in red blood cell formation, oxygen transport, energy metabolism and may improve oxygenation, so it’s good for patients who are anemic or suffer from fatigue.6
Active folate supports monoamine neurotransmitter synthesis (serotonin, dopamine, norepinephrine), improving mood regulation, especially in postpartum and perimenopausal women.7 It also crosses the blood-brain barrier to support cognitive health, potentially reducing the risk of age-related memory loss and dementia.
Quatrefolic outperforms high-dose folic acid
The same homocysteine metabolism studies noted above that show folate reduces heart disease risk confirm Quatrefolic folate matches and often outperforms high-dose folic acid supplementation. In a 2016 trial involving hypertensive patients with elevated homocysteine levels, 400 mcg of Quatrefolic combined with B6 and B12 reduced homocysteine from 21.5 µmol/L to 10.0 µmol/L. That’s a 55.8% normalization rate—significantly better than folic acid at 5 mg/day.
Unlike folic acid, Quatrefolic does not accumulate as unmetabolized folic acid (UMFA), which may block active folate uptake in the brain and interfere with methylation-dependent processes.8
Folate in Greens First Pro
With this reformulation to include Quatrefolic, Greens First Pro isn’t just adding folate —it’s addressing widespread nutritional gaps many patients don’t even know they have. Folate deficiency is linked to conditions ranging from depression to infertility to metabolic syndrome. And with MTHFR polymorphisms common but rarely tested for, DCs can feel confident recommending a formula that works across genetic types.
In addition to Quatrefolic, the gold standard in folate supplementation, Greens First Pro also includes more than 35 organic superfoods supporting cellular health, digestion, detoxification and inflammation balance, adaptogenic botanicals including organic ashwagandha, maca and holy basil, mushroom extracts for bolstering immune resilience and supporting the brain, and enzymes and probiotics for improved absorption and gut health.
Plus, it’s all available in a new peach mango flavor.
Recommend Greens First Pro with confidence
Greens First Pro is formulated with high-quality ingredients and with clinical outcomes in mind. By delivering active folate along with a synergistic matrix of plant-based nutrients, it supports whole-body function—not just treatment of symptoms.
This means one nutritional product that offers support for:
- Energy and recovery
- Cardiovascular health
- Hormonal balance
- Cognitive clarity
- Reproductive functioning
- Healthy aging
It’s also gluten-free, rigorously tested and backed by published scientific research. And because it’s a powdered superfood base, patients are more likely to stick with it than they are with pill-based folate options.
The right folate for real patients
Quatrefolic’s inclusion in Greens First Pro means a smarter, more personalized supplement—with no need for you or patients to decode genetic results first. Even if you’ve discussed Greens First with a patient before, the change in formula offers you a good entry point into a discussion about the many ways folate is essential to a healthy body and gives patients another reason to give it a try as part of their daily routine.
Whether your patients want to optimize their fertility, manage chronic fatigue, prevent heart health issues or simply support mood and keep their thinking sharp as they age, Greens First Pro offers a reliable bioavailable form of folate, one of the most essential nutrients in human physiology.
Learn more about the full Greens First Pro formula and its applications at greensfirst.com.
References
- Moll S, Varga E. Homocysteine and MTHFR mutations. Circulation. . Accessed July 31, 2025.
- Wald NJ. Folic acid and neural tube defects: Discovery, debate and the need for policy change. J Med Accessed July 31, 2025.
- Fekete K et al. Effect of folate intake on health outcomes in pregnancy: A systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr J. 2012;11:75. https://pmc.ncbi.nlm.nih.gov/articles/PMC3499376/. Accessed July 28, 2025.
- Yatsenko SA, Rajkovic A. Genetics of human female infertility. Biol Reprod. 2019101(3):549-566. https://pubmed.ncbi.nlm.nih.gov/31077289/. Accessed July 28, 2025.
- Mazza A, et al. Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. J Biol Regul Homeost Agents. 2016;30(3):921-927. https://pubmed.ncbi.nlm.nih.gov/27655522/. Accessed July 28, 2025.
- Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology and etiology in low- and middle-income countries. Ann NY Acad Sci. 2019;1450:15-31. https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.14092. Accessed July 28, 2025.
- Yan J, et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression. Nutrients. 2017;9(11):1206. https://pmc.ncbi.nlm.nih.gov/articles/PMC5707678/. Accessed July 28, 2025.
