• Magazine
    • Current Issue
    • Past Issues
    • Subscribe
    • Change Mailing Address
    • Surveys
    • Guidelines for Authors
    • Editorial Calendar and Deadlines
    • Dynamic Chiropractic
      • Newspaper
      • Subscription
    • The American Chiropractor
      • Magazine
  • Practice
    • Business Tips
    • Chiropractic Schools
    • Clinical & Technique
    • Ebooks
    • Ecourses
    • Sponsored Content
    • Infographics
    • Quizzes
    • Wellness & Nutrition
    • Podcast
  • Content Hubs
  • Products & Services
    • View Products & Services Directory
    • Browse Buyers Guide
    • Submit a Product
    • Vendor Login
  • Datebook
    • View Events
    • Post an Event
    • Become an Events Poster
  • Advertise
    • Advertising Information
    • Media Kit
    • Contact Us

Your Online Practice Partner

Chiropractic Economics
Your Online Practice Partner
Advertise Subscribe
  • Home
  • News
  • Webinars
  • Chiropractic Research
  • Students/New DCs

Study: probiotic supplementation reduces atopic dermatitis

Chiropractic Economics June 15, 2010

June 15, 2010 — A clinical study using probiotic mixture containing L. acidophilus DDS-1 and B. lactis UABLA-12 demonstrated significant clinical improvement in preschool children with atopic dermatitis (AD).

A clinical study to determine the impact of a mixture of L. acidophilus DDS-1 and B. lactis UABLA-12 on 90 preschool children (ages 1-3 years) with moderate to severe AD vs. a placebo demonstrated a 33.7 percent decrease in SCORAD (scoring of atopic dermatitis) versus 19.4 percent in the placebo group.

Other outcome measures included IDQOL (infant dermatitis quality of life 33 percent increase in probiotic group vs. 19 percent in placebo) and DFI (dermatitis family impact 34.4 percent in probiotic group vs. 23.8 percent in placebo).

This paper will be presented at the New York Academy of Sciences symposium, Probiotics: From Bench to Market, on June 11, 2010. The conference is designed to bring together scientists from industry, academia and government to discuss the emerging science of mechanisms behind the possible benefits of probiotic microorganisms in promoting human health and combating disease.

The study on probiotic supplementation on preschool children with AD was conducted by Dr. SV Gerasimov, MD, PhD from the Department of Pediatrics, Lviv National Medical University, Lviv, Ukraine. AD is a common inflammatory skin disorder that affects 15.6 percent of the population in Europe and 17.2 percent and is steadily increasing in frequency. The disease often occurs in early childhood and persists into adult life (over 60 percent of patients).

Current treatments include skin hydration, emollients, avoidance of allergens and irritants, use of antihistamines or topical corticosteroids. These treatments may alleviate symptoms but are often ineffective. The therapeutic use of probiotics has attracted considerable attention after publication of the hygiene hypothesis (Strachan DP. Hay fever, hygiene and household size. BMJ 1989;299:1259-60.)

Several clinical studies have demonstrated mild to complete resolution of AD following treatment with probiotics while others have suggested the effect is limited to select children with atopy.

This study was designed to determine the clinical efficacy of a new probiotic preparation and to determine the impact on peripheral lymphocytes.

The study involved 90 preschool children randomly divided into two groups to receive either the probiotic or the placebo. Parents administered the doses twice per day to provide a total of 10 billion CFU/gram of a combination of Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABLA-12 with FOS. The primary outcome measure was percent change in SCORAD index at week 8.

Secondary outcomes were changes in IDQOL, DFI at weeks 2, 4, 8, frequency and amount of topical corticosterioid used and absolute number and percent of peripheral blood lymphocyte subsets at week 8. Patients displayed a progressive decline in SCORAD indexes reaching significant difference at week 4 in both groups. However children receiving probiotics experienced a more rapid decline (summarized in table)

Treatment Group

Decrease in SCORAD

Week 2

Decrease in SCORAD

Week 4

Decrease in SCORAD

Week 8

Probiotic

-4.7

-8.7

-14.2

Placebo

-2.5

-5.1

-7.8

Patients with active AD had a reduced percentage of CD3 and CD8 peripheral lymphocytes and increased CD4 and CD25 counts. Hypothetically, the recovery from AD due to use of probiotics may be accompanied by normalization of CD3, CD4, CD8 and CD25 numbers. The study showed a correlation between reduction in CD4 and CD25 percent/absolute number and SCORAD values at week 8 in the probiotic group.

The use of a probiotic mixture containing L. acidophilus DDS-1, B. lactis UABLA-12 and fructooligosaccharide was associated with significant clinical improvement in children with AD, and corresponding lymphocyte subset changes in peripheral blood. The efficacy of probiotic therapy in adults with AD will need more investigation.

Source: UAS Laboratories, www.uaslabs.com

Related Posts

  • Northwestern Health Sciences University announces faculty promotionsNorthwestern Health Sciences University announces faculty promotions
  • Logan College of Chiropractic offers post-9/11 financial aid to military veteransLogan College of Chiropractic offers post-9/11 financial aid to military veterans
  • The International Federation of Chiropractors and Organizations looking for a few good leadersThe International Federation of Chiropractors and Organizations looking for a few good leaders
  • Best selling author to speak on reversing ‘diabesity’ at Metagenics University seminarBest selling author to speak on reversing ‘diabesity’ at Metagenics University seminar
  • Life West's director of research elected CCE councilorLife West's director of research elected CCE councilor

Filed Under: Industry News, News

Current Issue

Issue 11 cover

Get Exclusive Content! Join our email list

Follow Us

  • Facebook
  • X (Twitter)
  • Instagram
  • LinkedIn
  • YouTube logoYouTube logoYouTube

Compare Subscriptions

Dynamic Chiropractic

The American Chiropractor

8430 Enterprise Circle, Suite 200

Lakewood Ranch, FL 34202

Phone 800-671-9966

CONTACT US »

Privacy Policy | Terms of Service

Copyright © Chiropractic Economics, A Gallagher Company. All Rights Reserved.

SUBSCRIBE TO THE MAGAZINE

Get Chiropractic Economics magazine
delivered to your home or office. Just
fill out our form to request your FREE
subscription for 20 issues a year,
including two annual Buyers Guides.

SUBSCRIBE NOW »

Women's health - Issue 11 of Chiropractic Economics magazine